Retinoic acid regulates aberrant nuclear localization of PML-RARα in acute promyelocytic leukemia cells

摘要: Abstract Acute promyelocytic leukemia (APL) is characterized by a specific t(15;17) translocation that fuses the retinoic acid receptor α (RARα) to novel gene product, PML. The involvement of RARα particularly intriguing in view efficient therapeutic effect (RA) this disease. In report, we show PML specifically localized within discrete subnuclear compartment corresponding nuclear bodies recognized patient autoimmune sera. APL cells, PML-RARα hybrid displays an abnormal localization and directs RXR other antigens into aberrant structures are tightly bound chromatin. This suggests could exert dominant negative diverting subset proteins from their natural sites action. Interestingly, treatment cells with RA induces complete relocalization each these proteins. We propose beneficial role promoting myeloid differentiation might be related its ability restore normal organization.