Chewing gum as a drug delivery system
作者： Margrethe Rømer Rassing
DOI: 10.1016/0169-409X(94)90028-0
关键词:
摘要: Abstract The potential of chewing gum as a drug delivery system together with different formulation principles and methods assessment are discussed in this article. release from is dependent upon its water solubility. Water-soluble substances released rapidly completely available which retard their to provide an extended profile. Slightly water-soluble drugs slowly incompletely require special techniques produce satisfactory Studies evaluating the application medicated non-medicated treatment local diseases oral cavity described. Specific examples use for dental health, smoking cessation antifungal therapy cited. Few suitable candidates incorporation into formulations intention systemic delivery. Know-how derived development manufacture already existing gum, supplemented today's knowledge pharmaceutical formulation, constitute basis medicinal tomorrow.
elsevier.com
sci-hub.se 参考文章(82)
K K Park, J W Bolton, B R Schemehorn, G K Stookey, Effect of sorbitol gum chewing on plaque pH response after ingesting snacks containing predominantly sucrose or starch. American Journal of Dentistry. ,vol. 3, pp. 185- 191 ,(1990)
James N. Rider, Ed L. Brunson, Walter G. Chambliss, Robert W. Cleary, Ahmed H. Hikal, Peggy H. Rider, Larry A. Walker, Christy M. Wyandt, Alan B. Jones, Development and Evaluation of a Novel Dissolution Apparatus for Medicated Chewing Gum Products Pharmaceutical Research. ,vol. 9, pp. 255- 259 ,(1992) , 10.1023/A:1018901826635
Benowitz Nl, Toxicity of nicotine: implications with regard to nicotine replacement therapy. Progress in Clinical and Biological Research. ,vol. 261, pp. 187- 217 ,(1988)
Christrup Ll, Angelo Hr, Kristensen F, Rasmussen Sn, Bonde J, Relative bioavailability of methadone hydrochloride administered in chewing gum and tablets. Acta pharmaceutica nordica. ,vol. 2, pp. 83- 88 ,(1990)
Claes Lundgren, Stefan Lichtneckert, Ove Ferno, Chewable smoking substitute composition ,(1974)
N. Koizumi, M. Fujii, R. Ninomiya, Y. Inoue, T. Kagawa, T. Tsukamoto, Studies on transitory laxative effects of sorbitol and maltitol Chemosphere. ,vol. 12, pp. 117- 124 ,(1983) , 10.1016/0045-6535(83)90187-X
Ohlsson C, Ferno O, Buffered smoking substitute compositions ,(1972)
K. Warren Clark, Donald A. M. Mackay, Daniel Schoenholz, Frank Witzel, Long-lasting flavored chewing gum including chalk-free gum base ,(1976)
Vincent A. Segreto, Ira L. Shannon, Effect of an enzyme chewing gum on whole saliva protease levels. Journal of oral therapeutics and pharmacology. ,vol. 4, pp. 51- ,(1967)
N. Koizumi, M. Fujii, R. Ninomiya, Y. Inoue, T. Kagawa, T. Tsukamoto, Studies on transitory laxative effects of sorbitol and maltitol Chemosphere. ,vol. 12, pp. 105- 116 ,(1983) , 10.1016/0045-6535(83)90186-8