Structure of an unusual S‐adenosylmethionine synthetase from Campylobacter jejuni

摘要: S-Adenosylmethionine (AdoMet) participates in a wide range of methylation and other group-transfer reactions also serves as the precursor for two groups quorum-sensing molecules that function regulators production virulence factors Gram-negative bacteria. The synthesis AdoMet is catalyzed by synthetases (MATs), ubiquitous family enzymes found species ranging from microorganisms to mammals. synthetase bacterium Campylobacter jejuni (cjMAT) an outlier among this homologous enzyme family, with lower sequence identity, numerous insertions substitutions, higher catalytic activity compared bacterial MATs. Alterations structure provide explanation its unusual dimeric quaternary relative Taken together several active-site new provides insights into improved kinetic properties alternative substrates.