Predictors of incidental gallbladder cancer in patients undergoing cholecystectomy for benign gallbladder disease

摘要: Background and Objectives Discovery of incidental gallbladder cancer (IGC) has become more frequent due to adoption laparoscopy. Gallbladder spillage during operation can disseminate worsen the prognosis. Methods Patients who underwent laparoscopic or open cholecystectomy for benign disease January 1996 August 2011 at two tertiary care facilities were reviewed. Unmatched controls randomly selected in 2:1 ratio. Preoperative variables compared between groups. Results Sixty-seven patients with IGC identified 134 controls. Mean age was 68 index cases 49 controls; 70% 75% female. Multivariate analysis showed that higher risk significantly associated age ≥ 65 (OR = 10.61, P < 0.0001), dilated bile ducts (OR = 4.76, P = 0.0028), presence wall thickening (OR = 4.39, P = 0.0003). This model yielded a very good area under curve receiver operating characteristic (AUC = 0.83) discriminating from controls. Conclusions IGC is likely be found when ≥65, thickening. suspicion should prompt surgeon careful not perforate approach, have lower threshold conversion if necessary. J. Surg. Oncol. 2013;107:118–123. © 2012 Wiley Periodicals, Inc.