Disposition and Metabolism of Malachite Green and Other Therapeutic Dyes in Fish

摘要: The triphenylmethane dye malachite green has been used in aquaculture worldwide for treatment of parasitic and fungal infections fish shellfish. Other dyes (i.e., acriflavine, methylene blue) exhibit similar antimicrobial properties are widely marketed external ornamental fish. None these compounds regulated use food production the United States. Concern about health risks associated with drug residues products prompted our studies uptake, metabolism, elimination selected channel catfish. Malachite was primary focus because its toxicological long history aquaculture. Analytical methods were developed determination parent compound metabolites tissues. Distribution persistence tissues, including edible flesh, characterized. This chapter summarizes current knowledge disposition metabolism other therapeutic aquatic species.