Lymphopenia as a novel marker of Clostridium difficile infection recurrence
作者： Valéry Lavergne , Yannick Beauséjour , Gilbert Pichette , Marc Ghannoum , Shih Hann Su
DOI: 10.1016/J.JINF.2012.11.001
关键词:
摘要: Summary Background Treatment of Clostridium difficile infection (CDI) is often limited by recurrence in 25% cases. The objective this study was to determine risk factors CDI during a provincial endemic. Methods Data prospectively collected for 1 year Montreal hospital. Inclusion criteria were: age ≥18 years; admission ≥72 h; diagnosis current admission; no the previous 3 months. Results A total 121 patients were included, which 42% female. Mean 77 years, with median Charlson comorbidity index 5. Forty (33%) had recurrent disease within 2 months initial treatment. There 20 deaths (17%) 2-month follow-up period. Higher independently associated older (HR = 2.26 each decade), female gender (HR = 1.56), and lymphopenia at completion treatment (HR = 2.18), while positive C. antitoxin serology protective (HR = 0.17). not either time diagnosis, underlying comorbidities, severity or episode, re-exposure antibiotics Conclusion Lymphopenia end appears be strong marker recurrence. This available inexpensive test may identify who are higher
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