Comparative neuropsychology and Korsakoff's syndrome. I.--Spatial and visual reversal learning.

摘要: Abstract Alcoholic Korsakoff's disease is associated with widespread cerebral damage. Damage to the hippocampus and its major connections has been linked directly severe anterograde amnesia observed in Korsakoff patients. However, since other brain regions also are destroyed chronic alcoholism, a thorough description of any additional behavioral abnormalities essential understanding alcoholic syndrome. Using spatial visual reversal-learning paradigms popular comparative physiological psychology, we have profound defects formation stimulus-reinforcement associations by group 12 Korsakoffs comparison 13 11 aphasic control subjects. A 15 patients Huntington's showed deficits on but not reversals, their poor visually-based performance was qualitatively different from that