Electrophysiologic basis for the antiarrhythmic actions of ranolazine.
作者： Charles Antzelevitch , Alexander Burashnikov , Serge Sicouri , Luiz Belardinelli
DOI: 10.1016/J.HRTHM.2011.03.045
关键词:
摘要: … of ranolazine has been demonstrated in the clinic, even in patients with structural heart disease. … actions and antiarrhythmic properties of ranolazine in preclinical and clinical studies. …
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Sean R Wilson, Benjamin M Scirica, Eugene Braunwald, Sabina A Murphy, Ewa Karwatowska-Prokopczuk, Jacqueline L Buros, Bernard R Chaitman, David A Morrow, None, Efficacy of Ranolazine in Patients With Chronic Angina: Observations From the Randomized, Double-Blind, Placebo-Controlled MERLIN–TIMI (Metabolic Efficiency With Ranolazine for Less Ischemia in Non–ST-Segment Elevation Acute Coronary Syndromes) 36 Trial Journal of the American College of Cardiology. ,vol. 53, pp. 1510- 1516 ,(2009) , 10.1016/J.JACC.2009.01.037
Michael J. Koren, Michael R. Crager, Michael Sweeney, Long-Term Safety of a Novel Antianginal Agent in Patients With Severe Chronic Stable Angina: The Ranolazine Open Label Experience (ROLE) Journal of the American College of Cardiology. ,vol. 49, pp. 1027- 1034 ,(2007) , 10.1016/J.JACC.2006.10.067
Samuel Sossalla, Birte Kallmeyer, Stefan Wagner, Marek Mazur, Ulrike Maurer, Karl Toischer, Jan D. Schmitto, Ralf Seipelt, Friedrich A. Schöndube, Gerd Hasenfuss, Luiz Belardinelli, Lars S. Maier, Altered Na+Currents in Atrial Fibrillation: Effects of Ranolazine on Arrhythmias and Contractility in Human Atrial Myocardium Journal of the American College of Cardiology. ,vol. 55, pp. 2330- 2342 ,(2010) , 10.1016/J.JACC.2009.12.055
Stanley Nattel, Denis Chartier, Paulus Kirchhof, Marc D Lemoine, Xiao Yan Qi, Larissa Fabritz, Abstract 11401: Electrophysiological Basis for Atrial Arrhythmia in a Long QT Syndrome Mouse Model Circulation. ,vol. 122, ,(2010)
ERIC N PRYSTOWSKY, JOHN CAMM, GREGORY Y.H. LIP, MAURITS ALLESSIE, JEAN-FRANÇOIS BERGMANN, GÜNTER BREITHARDT, JOSEP BRUGADA, HARRY CRIJNS, PATRICK T. ELLINOR, DANIEL MARK, GERALD NACCARELLI, DOUGLAS PACKER, JUAN TAMARGO, The impact of new and emerging clinical data on treatment strategies for atrial fibrillation. Journal of Cardiovascular Electrophysiology. ,vol. 21, pp. 946- 958 ,(2010) , 10.1111/J.1540-8167.2010.01770.X
Sandra Fredj, Kevin J Sampson, Huajun Liu, Robert S Kass, Molecular basis of ranolazine block of LQT-3 mutant sodium channels: evidence for site of action British Journal of Pharmacology. ,vol. 148, pp. 16- 24 ,(2006) , 10.1038/SJ.BJP.0706709
Shaobin Jia, Jiangfan Lian, Donglin Guo, Xiaolin Xue, Chinmay Patel, Lin Yang, Zuyi Yuan, Aiqun Ma, Gan-Xin Yan, Modulation of the late sodium current by ATX-II and ranolazine affects the reverse use-dependence and proarrhythmic liability of IKr blockade British Journal of Pharmacology. ,vol. 164, pp. 308- 316 ,(2011) , 10.1111/J.1476-5381.2010.01181.X
Yejia Song, John C. Shryock, Lin Wu, Luiz Belardinelli, Antagonism by ranolazine of the pro-arrhythmic effects of increasing late INa in guinea pig ventricular myocytes. Journal of Cardiovascular Pharmacology. ,vol. 44, pp. 192- 199 ,(2004) , 10.1097/00005344-200408000-00008
Andrew C. Zygmunt, Vladislav V. Nesterenko, Sridharan Rajamani, Dan Hu, Hector Barajas-Martinez, Luiz Belardinelli, Charles Antzelevitch, Mechanism of the Preferential Block of the Atrial Sodium Current by Ranolazine Biophysical Journal. ,vol. 96, ,(2009) , 10.1016/J.BPJ.2008.12.1229
Kurt C. Roberts-Thomson, Irene Stevenson, Peter M. Kistler, Haris M. Haqqani, Steven J. Spence, John C. Goldblatt, Prashanthan Sanders, Jonathan M. Kalman, The role of chronic atrial stretch and atrial fibrillation on posterior left atrial wall conduction Heart Rhythm. ,vol. 6, pp. 1109- 1117 ,(2009) , 10.1016/J.HRTHM.2009.04.008