Diurnal rhythms in intraocular pressure, axial length, and choroidal thickness in a primate model of eye growth, the common marmoset.

摘要: PURPOSE. In chickens, there are circadian rhythms in axial length, choroidal thickness, and intraocular pressure (IOP), the phases of which differ, depending on visual manipulations that alter ocular growth rate. this study, these same were sought common marmoset, a primate model eye growth, to establish whether may play role regulation across species. METHODS. IOP was measured by applanation tonometry 14 untreated marmosets ranging age from 24 259 days. High-frequency A-scan ultrasonography used measure dimensions (axial length thickness) 12 572 Four monkeys when they juveniles (110 days age) again later, adolescents. Measurements typically made at 12-hour intervals, although three animals 6-hour intervals. Nine had both experiment. RESULTS. There diurnal rhythm marmosets: higher during dark period lower light (mean change, 3.6 mm Hg; P 0.005). also thickness. The dependent age, with fastergrowing eyes increasing day decreasing night (25 m vs. –22 m; 0.001) slower-growing adolescents showing opposite pattern (27 46 0.0001). choroid thickened thinned day, all ages (19 –16 CONCLUSIONS. Diurnal IOP, thickness exist primates. Age-related differences phase relationships be associated rates growth. (Invest Ophthalmol Vis Sci. 2002;43:2519 –2528)