Denervation supersensitivity to 5-hydroxytryptamine in the rat spinal cord is not due to the absence of 5-hydroxytryptamine.
作者： Louis E. Tremblay , Paul J. Bédard , Ronald Maheux , Thérèse Di Paolo
DOI: 10.1016/0006-8993(85)90023-X
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摘要: Abstract d,l -5-Hydroxytryptophan and 5-HT agonists administered systemically, stimulate motoneuronal discharges as measured by the spontaneous EMG activity of hindlimbs in paraplegic rats. Denervation supersensitivity is observed after surgical section spinal cord or treatment with 5,7-dihydroxytryptamine (5,7-DHT). Such denervation supersensitivity, however, cannot be reproduced equivalent depletion synthesis inhibition reversed chronic intrathecal administration agonists. These results suggest that anterior horn cord, trigger to serotonin not absence neurotransmitter itself but terminals some other compound contained therein.
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