摘要: Epidemiologists in Japan have been performing calculations to estimate nationwide cancer incidence rates as well 5-year survival using population-based registry data. There remarkable changes and/or mortality cancers of the lung, liver and stomach, which were thought be attributed changing impact exposure cigarette smoking, chronic hepatitis C virus infection Helicobacter pylori infection, respectively. In systematic reviews providing evidence risk/protective factors for sites case-control cohort studies Japanese population, there associations between (esophagus, colo-rectum, liver, pancreas, lung breast) various lifestyle factors. past 10 years, a hospital-based study at Aichi Cancer Center provided valuable gene-environment interaction on development [i.e., effects aldehyde dehydrogenase-2 (ALDH2) polymorphism heavy alcohol drinking esophageal cancer, ALDH2 smoking methylenetetrahydrofolate reductase pancreatic cancer]. The database with stored DNA was also used identified seven loci containing significant but low-penetrance polymorphisms associated breast cancer. These findings together established risk are likely useful predict personalized East Asian women. 2005, Multi-Institution Collaborative Cohort (J-MICC) launched elucidate interactions confirm preclinical diagnostic biomarkers J-MICC, has recruited 92,000 healthy individuals by end 2012, will follow until 2025.
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