Valacyclovir Prophylaxis to Prevent Recurrent Herpes at Delivery

摘要: Objective To measure the efficacy of valacyclovir suppression in late pregnancy to reduce incidence recurrent genital herpes labor and subsequent cesarean delivery. Methods A total 350 pregnant women with a history were assigned randomly oral 500 mg twice day or an identical placebo from 36 weeks gestation until In labor, vulvovaginal simplex virus (HSV) culture polymerase chain reaction (PCR) specimens collected. Vaginal delivery was permitted if no clinical recurrence prodromal symptoms present. Neonatal HSV cultures laboratory tests obtained, infants followed up for 1 month after Data analyzed using chi2 Student t tests. Results One hundred seventy treated 168 evaluated. Eighty-two percent had herpes; 12% first episode, nonprimary 6% primary herpes. At delivery, 28 (8%) requiring delivery: 4% group 13% (P = .009). Herpes detected by 2% 9% [corrected] =.02). No diagnosed neonatal HSV, there significant differences complications. There maternal obstetric complications either group. Conclusion Valacyclovir significantly reduces shedding Level evidence I.