The discovery of half-sandwich iridium complexes containing lidocaine and (pyren-1-yl)ethynyl derivatives of phenylcyanamide ligands for photodynamic therapy
摘要: … Among the metal-based PDT, a ruthenium-based photosensitizer (TLD-1433) has recently been approved for phase Ib clinical trials in Canada for non-muscle invasive bladder cancer. …
Zhe Liu, Abraha Habtemariam, Ana M. Pizarro, Sally A. Fletcher, Anna Kisova, Oldrich Vrana, Luca Salassa, Pieter C. A. Bruijnincx, Guy J. Clarkson, Viktor Brabec, Peter J. Sadler, Organometallic Half-Sandwich Iridium Anticancer ComplexesJournal of Medicinal Chemistry. ,vol. 54, pp. 3011- 3026 ,(2011) , 10.1021/JM2000932