Optimal Vitamin D Supplementation Doses that Minimize the Risk for Both Low and High Serum 25-Hydroxyvitamin D Concentrations in the General Population.

摘要: The Recommended Dietary Allowance (RDA) is the nutrient intake considered to be sufficient meet requirements of 97.5% population. Recent reports revealed a statistical error in calculation RDA for vitamin D opening question what recommendation should be. We took dual approach answer this question: (1) we aggregated 108 published estimates on supplementation and status; (2) analyzed 13,987 observations program participants. aggregation data that 2909 IU per day needed achieve serum 25-hydroxyvitamin (25(OH)D) concentrations 50 nmol/L or more healthy individuals. For normal weight, overweight obese participants was 3094, 4450 7248 respectively. These doses would also result 2.5% having 25(OH)D above 210, 200 214 As these are high, an minimizes risk both low high seems desirable. With estimated, example, 1885, 2802 6235 required individuals respectively natural (defined as 58 171 nmol/L). In conclusion, large extent variability makes neither desirable nor feasible. therefore propose recommendations articulated form optimal concentrations. This contribution includes body weight specific intakes various combinations lower upper concentration targets.