Klotho Prevents Translocation of NFκB
作者： P. Buendía , R. Ramírez , P. Aljama , J. Carracedo
DOI: 10.1016/BS.VH.2016.02.005
关键词:
摘要: Klotho protein is a β-glucuronidase capable of hydrolyzing steroid β-glucuronides. Two molecules are produced by the gene, membrane bound form and circulating form. This recognized as an antiaging gene with pleiotropic functions. The activation cellular systems associated pathogenesis several chronic degenerative diseases inflammatory state. Inflammation characterized NFκB. suppresses nuclear factor NFκB subsequent transcription proinflammatory genes. review focuses on current understanding function its relationship regulation, emphasizing potential involvement in pathophysiologic process.
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