Rhodium-catalyzed asymmetric hydroamination and hydroindolation of keto-vinylidenecyclopropanes
作者： Song Yang , Quan-Zhe Li , Chen Xu , Qin Xu , Min Shi
DOI: 10.1039/C8SC01595C
关键词:
摘要: We reported a highly regio- and enantioselective hydroamination hydroindolation of keto-vinylidenecyclopropanes via cationic Rh(i) catalysis in this context. The combination various secondary amines indoles with afforded the corresponding hydrofunctionalization products good to excellent yields outstanding ee values under mild conditions. A new TMM-Rh model complex was proposed, providing an atom economical Rh-π-allyl precursor at same time. Moreover, resulting could easily be transformed into more polyheterocycles upon further synthetic manipulation.
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