Association of interleukin-10 gene variation with breast cancer prognosis

摘要: Genetic polymorphisms are responsible for inter-individual variation and diversity have been recently considered as the main genetic elements involved in development progression of cancer. We examined associations between common germline variants 7 genes folate metabolism, cell proliferation apoptosis, prostaglandin synthesis, detoxification compounds inflammation, disease-free survival among women diagnosed with invasive breast DNA from up to 432 was genotyped 8 polymorphisms. The genotypes each polymorphism were tested association using univariate multivariate Cox regression analysis. model adjusted known cancer prognostic factors. rare allele IL-10 592C>A significantly associated reduced (P = 0.018, risk ratio recurrence (RR) 1.45, 95% confidence interval (CI) 1.06-1.98), which not attenuated after adjusting age at diagnosis, tumor size, lymph node status, clinical stage, histological grade, estrogen receptor progesterone treatment modalities 0.019, RR 1.48, CI 1.066-2.044). No found MTHFR 677C>T, TGFB1 29T>C, FASLG 844C>T, FAS 1377G>A, 670A>G, PTGS2 8473T>C SULT1A1 638G>A survival. Our data suggest that may be a potential marker