Autism Spectrum Disorder from the Womb to Adulthood: Suggestions for a Paradigm Shift.

摘要: The wide spectrum of unique needs and strengths Autism Spectrum Disorders (ASD) is a challenge for the worldwide healthcare system. With plethora information from research, common thread required to conceptualize an exhaustive pathogenetic paradigm. epidemiological clinical findings in ASD cannot be explained by traditional linear genetic model, hence need move towards more fluid conception, integrating genetics, environment, epigenetics as whole. embryo-fetal period first two years life (the so-called ‘First 1000 Days’) are crucial time window neurodevelopment. In particular, interplay vicious loop between immune activation, gut dysbiosis, mitochondrial impairment/oxidative stress significantly affects neurodevelopment during pregnancy undermines health people throughout life. Consequently, most effective intervention expected primary prevention aimed at early control main effector molecular pathways. We will reason here on comprehensive paradigm ASD, viewed not just theoretical issue, but tool provide suggestions preventive strategies personalized, dynamic (from womb adulthood), systemic, interdisciplinary approach.