Meta-analysis supports association of a functional SNP (rs1801133) in the MTHFR gene with Parkinson's disease.
作者： Zhi-gang Zhu , Qing-long Ai , Wen-min Wang , Zhi-cheng Xiao
DOI: 10.1016/J.GENE.2013.07.034
关键词:
摘要: Abstract The MTHFR is a candidate risk gene for Parkinson's disease (PD), and functional SNP (rs1801133) in the coding region of this has been investigated associations with illness extensively among worldwide populations, but overall results were inconsistent. Here, to assess relationship between rs1801133 PD general we conducted systematic meta-analysis by combining all available case–control samples European Asian total 1820 cases 7530 healthy controls, pooled odds ratios (ORs) 95% confidence intervals (95% CIs) calculated using Mantel–Haenszel method fixed-effect model. Overall, was significantly associated (allelic model, OR = 1.212 T allele, CI = 1.097–1.340, p-value = 0.0002). When stratifying ethnicity, significant association also observed OR = 1.187 CI = 1.058–1.332, p-value = 0.004) OR = 1.293 CI = 1.058–1.580, p-value = 0.012) respectively. In addition, mRNA expression both CEU (European, p-value = 0.0149) CHB (Chinese, p-value = 0.0178) HapMap populations. Collectively, our suggests that susceptibility likely an authentic PD.
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