Correlation between the occurrence of Ki-67 antigen and clinical parameters in human breast carcinoma.

摘要: Cryostat sections of ductal breast carcinomas obtained during surgery from 48 patients were subjected to an indirect immunostaining with antibody against Ki-67 antigen (Dako). The primary reaction was visualized by the APAAP technique new fuchsin as chromogen. percentage positively stained nuclei correlated tumor size, number metastatic lymph nodes, presence or absence metastases in distant organs well patient's age. best correlations achieved when data considered separately within groups low, medium and high values. A possible significance evaluation for prognosis therapy is discussed.