MiR-34, SIRT1 and p53 : The feedback loop

摘要: MicroRNAs (miRNAs) are small non-coding RNAs that regulate gene expression. Several studies have linked dysregulation of miRNA with tumorigenesis. The TP53 is one the most commonly mutated genes in human cancers, and its product p53 activates transcription a set including miR-34 family miRNA. regulates cell cycle progression, cellular senescence apoptosis, but targets not completely defined. We recently found miR-34a inhibits SIRT1, limits longevity. SIRT1 also dependent apoptosis through deacetylating stabilizing p53. discovered mediates activation by regulating activity. Based on this observation, we propose positive feedback loop, which induces expression suppresses increasing