Comparison of the Cellular Pharmacokinetics and Toxicity of 2′,2′-Difluorodeoxycytidine and 1-β-d-Arabinofuranosylcytosine
作者： Larry W. Hertel , William K Plunkett , Gerald B. Grindey , Volker Heinemann
DOI:
关键词:
摘要: Abstract 2′, 2′-Difluorodeoxycytidine (dFdC) is a new deoxycytidine analogue with good activity against human leukemic cell lines and murine solid tumors, while the activity of 1-β-d-arabinofuranosylcytosine (ara-C) is established in experimental systems and for the treatment of human adult leukemia. This study compared the cellular metabolism and cytotoxic properties of dFdC and ara-C in Chinese hamster ovary cells. In wild-type cells, dFdC was significantly more cytotoxic than ara-C after both 4-and 18-h incubations. The 5 …
aacrjournals.org
researchgate.net 参考文章(27)
Alan R. P. Paterson, Gilles J. Lauzon, Andrew W. Belch, Formation of 1-beta-D-arabinofuranosylcytosine diphosphate choline in neoplastic and normal cells. Cancer Research. ,vol. 38, pp. 1730- 1733 ,(1978)
Corwin Herman Hansch, Albert Leo, Substituent constants for correlation analysis in chemistry and biology Published in <b>1979</b> in New York NY) by Wiley. ,(1979)
F. L. Graham, G. F. Whitmore, Studies in mouse L-cells on the incorporation of 1-beta-D-arabinofuranosylcytosine into DNA and on inhibition of DNA polymerase by 1-beta-D-arabinofuranosylcytosine 5'-triphosphate. Cancer Research. ,vol. 30, pp. 2636- 2644 ,(1970)
Harvey D. Preisler, Youcef M. Rustum, Correlation between Leukemic Cell Retention of 1-β-d-Arabinofuranosylcytosine 5′-Triphosphate and Response to Therapy Cancer Research. ,vol. 39, pp. 42- 49 ,(1979)
William Plunkett, Donna S. Shewach, Cellular Retention of 9-β-d-Arabinofuranosyladenine 5′-Triphosphate and the Pattern of Recovery of DNA Synthesis in Chinese Hamster Ovary Cells Cancer Research. ,vol. 46, pp. 1581- 1584 ,(1986)
J.S. Wiley, S.P. Jones, W.H. Sawyer, Cytosine arabinoside transport by human leukaemic cells European Journal of Cancer and Clinical Oncology. ,vol. 19, pp. 1067- 1074 ,(1983) , 10.1016/0277-5379(83)90029-9
Donna S. Shewach, William Plunkett, Effect of 2′-deoxycoformycin on the inhibition of deoxyribonucleic acid synthesis by 9-β-d-arabinofuranosyladenine 5′-triphosphate☆ Biochemical Pharmacology. ,vol. 31, pp. 2103- 2109 ,(1982) , 10.1016/0006-2952(82)90427-0
A. O. HAWTREY, T. SCOTT-BURDEN, G. ROBERTSON, Inhibition of glycoprotein and glycolipid synthesis in hamster embryo cells by cytosine arabinoside and hydroxyurea Nature. ,vol. 252, pp. 58- 60 ,(1974) , 10.1038/252058A0
RONALD Y. CHUANG, LINDA F. CHUANG, Inhibition of RNA polymerase as a possible anti-leukaemic action of cytosine arabinoside. Nature. ,vol. 260, pp. 549- 550 ,(1976) , 10.1038/260549A0
E.A. Hiss, R.J. Preston, The effect of cytosine arabinoside on the frequency of single-strand breaks in DNA of mammalian cells following irradiation or chemical treatment. Biochimica et Biophysica Acta. ,vol. 478, pp. 1- 8 ,(1977) , 10.1016/0005-2787(77)90238-6