An Expanded View of the Phagocytic Respiratory Burst

摘要: Baldridge and Gerard in 19331 made the seminal observation that leukocyte consumption of ambient O2 increases markedly during early stages phagocytosis. Over ensuing 43 years remarkable progress was characterizing mechanisms ramifications this phenomenon, identified by Babior as respiratory burst.2 Consumption neutrophils monocytes phagocytosis leads to purposeful formation superoxide, a unique capacity phagocytic cells. Production superoxide subsequent other reactive oxygen intermediates (e.g., H2O2 OCl-) is critical microbicidal activity these cells.3 This graphically demonstrated natural history patients with chronic granulomatous disease (CGD) childhood, whose phagocytes lack develop burst.3, 4