Animal models of anxiety and anxiolytic drug action.

摘要: Animal models of anxiety attempt to represent some aspect the etiology, symptomatology, or treatment human disorders, in order facilitate their scientific study. Within this context, animal anxiolytic drug action can be viewed as relevant pharmacological control anxiety. A major purpose these is identify novel compounds and study mechanisms whereby produce effects. After a critical analysis “face,” “construct,” “predictive” validity, biological context which are evaluated specified. We then review terms general profiles, with particular attention sensitivity 5-HT1A agonists antidepressant compounds. Although there important exceptions, most sensitive one perhaps two classes compounds, limiting generality somewhat, but allowing depth individual (e.g., GABAA agonism). end discussion possible sources variability between response drugs.