Hepatobiliary cystadenoma and cystadenocarcinoma. A light microscopic and immunohistochemical study of 70 patients.

摘要: Fifty-two hepatobiliary cystadenomas and 18 cystadenocarcinomas were drawn from the files of Armed Forces Institute Pathology Rhode Island Hospital studied in an attempt to correlate light microscopic features tumors with immunohistochemical follow-up data. The cystadenoma patients ranged age 2 87 years at time initial diagnosis (mean, 45 years). All multilocular benign cuboidal columnar epithelium, 44 (85%) had densely cellular spindle cell ("ovarian-like") stromata; 96% female. Fifty-one macrocystic lesions, typically lined by mucinous epithelium; one lesions was a serous (microcystic adenoma) reminiscent more commonly encountered pancreatic lesion same name. cystadenocarcinoma 24 90 first 59 years); eight (44%) male. but malignant situ (one case) or invasive tubulopapillary (15 cases), solid case), adenosquamous epithelial components. Areas preexisting found six (33%), observation suggesting that may evolve into ones some patients. Most arose liver, few extrahepatic biliary system (including gallbladder). On follow-up, general successfully treated surgical excision toto; subtotal resection often persistent symptomatic disease. Four died their tumors; another two alive disease last follow-up. In both most tumor cells positive on staining antibodies cytokeratin, membrane antigen, carcinoembryonic antigen; scattered chromogranin-positive also appeared types. Immunohistochemistry did not yield diagnostic immunoprofile distinguish other arising within abdominal cavity. At least types exist, developing exclusively female patients, usually accompanied "ovarian-like" stroma, which follows indolent course; other, lacking distinctive seen males, aggressive course is likely result patient's death tumor. It remains open question whether mesenchymal arise women, will follow as similar men.