Current biosensor technologies in drug discovery

摘要: Over the past two decades benefits of biosensor analysis have begun to make an impact in market, and systems are beginning be used as mainstream research tools many laboratories1,2. Biosensors devices that use biological or chemical receptors detect analytes a sample.They give detailed information on binding affinity, cases also kinetics interaction.Typically, receptor molecule must connected some way transducer produces electrical signal real-time. Labelfree biosensors do not require reporter elements (fluorescent, luminescent, radiometric, colorimetric) facilitate measurements. Detailed interaction can obtained during while minimising sample processing requirements assay run times3. Unlike label- reporter-based technologies simply confirm presence detector molecule, label-free techniques provide direct analyte target molecules typically form mass addition depletion from surface sensor substrate, measuring changes heat capacity sample4. However, these failed gain widespread acceptance due technical constraints, low throughput, high user expertise requirements, cost.While they powerful hands skilled evaluating purified samples, readily adapted every day lab where simple understand results numbers samples norm.This article seeks address issues surrounding un-met needs market place, difficulties faced by technology developers meeting with innovative products. It reviews recent entries newer who race release products for primary secondary drug screening, mode action studies, screening pharmacokinetic properties.