Process for the preparation of 3-, 6-substituted 2,5-morpholinediones

摘要: A process for making 2,5-morpholinediones of structure (I), wherein each R is independently hydrogen, C1-C12 hydrocarbyl, or substituted hydrocarbyl and at least one by reacting an ester free acid N-(α-hydroxyacyl)-α- amino substrate (II) R3 C?1?-C12 over a fixed bed catalyst, the reaction being carried out about 150 °C to 350 °C, followed collection effluent product. Such morpholinediones are useful as precursors preparation depsipeptide polymers copolymers.