Asymmetric transformations of achiral 2,5-cyclohexadienones.
作者： Kyle A. Kalstabakken , Andrew M. Harned
DOI: 10.1016/J.TET.2014.07.081
关键词:
摘要: Cyclohexadienones are versatile platforms for performing asymmetric synthesis as evidenced by the numerous natural product syntheses that exploit their diverse reactivity profile. However, there few general methods available direct of chiral cyclohexadienones. To circumvent this problem, several researchers have developed catalytic employ readily achiral 2,5-cyclohexadienones substrates. Many these reactions desymmetrizations in which one enantiotopic alkenes an dienone is transformed. Others involve selective reaction at alkene unsymmetrically substituted, dienone. This review will cover advances area over last 20 years and application strategies complex molecule synthesis.
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