Regioselective Synthesis of Multisubstituted Furans via Metalloradical Cyclization of Alkynes with α-Diazocarbonyls: Construction of Functionalized α-Oligofurans
作者： Xin Cui , Xue Xu , Lukasz Wojtas , Martin M. Kim , X. Peter Zhang
DOI: 10.1021/JA309446N
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摘要: Co (III)–carbene radicals generated from activation of α-diazocarbonyls by Co (II)–porphyrin complexes have been shown to undergo a new type of tandem radical addition reaction with alkynes that affords five-membered furan structures. The Co (II) complex of 3, 5-Di t Bu-IbuPhyrin,[Co (P1)], is effective in catalyzing the metalloradical cyclization reaction under neutral and mild conditions. The [Co (P1)]-catalyzed process tolerates a wide range of α-diazocarbonyls and terminal alkynes with varied steric and electronic properties, producing …
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