Canaux sodiques et canalopathies : douleurs neuropathiques, épilepsies, migraine
作者： S. Cestèle , M. Mantegazza
DOI: 10.1007/S11724-016-0478-8
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摘要: Les canaux sodiques dependants du potentiel sont les acteurs majeurs de l’excitabilite neuronale. Leur role est exacerbe par la mise en evidence mutations qui alterent leur fonctionnement. La diversite des (plusieurs isoformes) ainsi que leurs differentes localisations font qu’ils impliques dans pathologies neurologiques telles douleurs neuropathiques, migraine et l’epilepsie. Une comprehension mecanismes physiopathologiques ces diverses permettra developper agents pharmacologiques dotes d’une grande specificite comblera un besoin therapeutique.
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