Fetal death: a condition with a dissociation in the concentrations of soluble vascular endothelial growth factor receptor-2 between the maternal and fetal compartments.

作者: Tinnakorn Chaiworapongsa , Juan Pedro Kusanovic , Zeynep Alpay Savasan , Shali Mazaki-Tovi , Sun Kwon Kim

DOI: 10.3109/14767050903410664

关键词:

摘要: OBJECTIVE An anti-angiogenic state has been implicated in the pathophysiology of preeclampsia, fetal growth restriction and death. Vascular endothelial factor (VEGF), an indispensible angiogenic for embryonic placental development exerts its properties through VEGF receptor (VEGFR)-2. A soluble form this protein (sVEGFR-2) recently detected maternal blood. The aim study was to determine if death associated with changes concentrations sVEGFR-2 plasma amniotic fluid.

参考文章(72)
Tinnakorn Chaiworapongsa, Roberto Romero, Jimmy Espinoza, Emmanuel Bujold, Yeon Mee Kim, Luis F Gonçalves, Ricardo Gomez, Samuel Edwin, Evidence supporting a role for blockade of the vascular endothelial growth factor system in the pathophysiology of preeclampsia: Young Investigator Award American Journal of Obstetrics and Gynecology. ,vol. 190, pp. 1541- 1547 ,(2004) , 10.1016/J.AJOG.2004.03.043
Makoto Taomoto, D Scott McLeod, Gerard A Lutty, Larry Witte, Zhenping Zhu, Jingtai Cao, Localization of VEGF receptor-2 (KDR/Flk-1) and effects of blocking it in oxygen-induced retinopathy. Investigative Ophthalmology & Visual Science. ,vol. 43, pp. 474- 482 ,(2002)
Rogelio González P, Ricardo Gómez M, René Castro S, Jyh Kae Nien, Paulina Merino O, Alejandra Etchegaray B, Mario Carstens R, Luis Medina H, Paola Viviani G, Iván Rojas T, Curva nacional de distribución de peso al nacer según edad gestacional: Chile, 1993 a 2000 Revista Medica De Chile. ,vol. 132, pp. 1155- 1165 ,(2004) , 10.4067/S0034-98872004001000001
Gordon CS Smith, KH Christina, Aris T Papageorghiou, Anna Maria Cacho, Kypros H Nicolaides, Fetal Medicine Foundation Second Trimester Screening Group, Maternal uterine artery Doppler flow velocimetry and the risk of stillbirth. Obstetrics & Gynecology. ,vol. 109, pp. 144- 151 ,(2007) , 10.1097/01.AOG.0000248536.94919.E3
Malini G. Kanagalingam, Scott M. Nelson, Dilys J. Freeman, William R. Ferrell, Lynne Cherry, Gordon D.O. Lowe, Ian A. Greer, Naveed Sattar, Vascular dysfunction and alteration of novel and classic cardiovascular risk factors in mothers of growth restricted offspring Atherosclerosis. ,vol. 205, pp. 244- 250 ,(2009) , 10.1016/J.ATHEROSCLEROSIS.2008.10.006
Donald S. Torry, Hsin-Shih Wang, Tzu-Hao Wang, Michael R. Caudle, Ronald J. Torry, Preeclampsia is associated with reduced serum levels of placenta growth factor American Journal of Obstetrics and Gynecology. ,vol. 179, pp. 1539- 1544 ,(1998) , 10.1016/S0002-9378(98)70021-3
Shin-Young Kim, So-Yeon Park, Jin-Woo Kim, Young-Mi Kim, Jae-Hyug Yang, Moon-Young Kim, Hyun-Kyong Ahn, Joong-Sik Shin, Joo-Oh Kim, Hyun-Mee Ryu, None, Circulating endothelial progenitor cells, plasma VEGF, VEGFR-1, and VEGFR-2 levels in preeclampsia American Journal of Obstetrics and Gynecology. ,vol. 193, ,(2005) , 10.1016/J.AJOG.2005.10.267
Roberto Romero, Jyh Kae Nien, Jimmy Espinoza, David Todem, Wenjiang Fu, Hwan Chung, Juan Pedro Kusanovic, Francesca Gotsch, Offer Erez, Shali Mazaki-Tovi, Ricardo Gomez, Sam Edwin, Tinnakorn Chaiworapongsa, Richard J. Levine, S. Ananth Karumanchi, A longitudinal study of angiogenic (placental growth factor) and anti-angiogenic (soluble endoglin and soluble vascular endothelial growth factor receptor-1) factors in normal pregnancy and patients destined to develop preeclampsia and deliver a small for gestational age neonate Journal of Maternal-fetal & Neonatal Medicine. ,vol. 21, pp. 9- 23 ,(2008) , 10.1080/14767050701830480