Vitamin D Metabolism and its Relationship to Pathologies of Calcium Metabolism

摘要: It is common belief among scientists, clinical scientists and practicing physicians that a deficiency of vitamin D brings about either the disease osteomalacia or rickets, both which are characterized by failure mineralization organic matrix newly synthesized bone. Although correct, this concept too narrow to encompass pathological states known in experimental animals suffering deficiency. The best example rat which, when placed on low calcium diet absence D, does not develop classical signs rickets even osteomalacia, but rather develops hypocalcemic tetany more like osteoporosis (1). On other hand, if same phosphorus symptoms