IL-4 Is Proangiogenic in the Lung under Hypoxic Conditions

摘要: IL-4-mediated proangiogenic and proinflammatory vascular responses have been implicated in the pathogenesis of chronic lung diseases such as asthma. Although it is well known that hypoxia induces pulmonary angiogenesis alterations, underlying mechanism IL-4 on vasculature under hypoxic conditions remains unknown. In this context, we designed present study to determine functional importance for using knockout (KO) animals. Our results show significantly increased IL-4Rα expression wild-type (WT) control lungs. Even though up-regulated endothelial growth factor (VEGF) receptor lungs both genotypes, hypoxia-induced VEGF, VCAM-1, HIF-1α, ERK phosphorylation were diminished KO compared with WT addition, proliferating activities airway artery suppressed We also isolated primary fibroblasts from these genotypes stimulated cells hypoxia. Hypoxia-induced VEGF production was mice. These vitro are accordance vivo data. Furthermore, observed a significant increase STAT6 mice similar controls. conclusion, has properties via pathway, independent pathway.