Alzheimer's disease amyloidogenic glycoprotein: expression pattern in rat brain suggests a role in cell contact.

摘要: The cloned cDNA encoding the rat cognate of human A4 amyloid precursor protein was isolated from a brain library. predicted primary structure 695-amino acid-long displays 97% identity to its homologue shown previously resemble an integral membrane protein. detected in rodent and muscle by Western blot analysis. Using situ hybridization immunocytochemistry on sections, we discovered that amyloidogenic glycoprotein (rAG) mRNA are ubiquitously abundantly expressed neurons indicating neuronal original for deposits observed humans with Alzheimer's disease (AD). appears patches or near plasma membranes suggesting role this cell contact. Highest expression seen regions where is deposited AD but also areas which do not contain AD. Since rarely brain, conclude high AG sole cause amyloidosis.