A Quantitative Pixel-Wise Measurement of Myocardial Blood Flow by Contrast-Enhanced First-Pass CMR Perfusion Imaging: Microsphere Validation in Dogs and Feasibility Study in Humans

摘要: Objectives The aim of this study was to evaluate fully quantitative myocardial blood flow (MBF) at a pixel level based on contrast-enhanced first-pass cardiac magnetic resonance (CMR) imaging in dogs and patients. Background Microspheres can quantify MBF subgram regions interest, but CMR perfusion may be able differentiate much higher resolution. Methods First-pass performed dog model with local hyperemia induced by intracoronary adenosine. Fluorescent microspheres were the reference standard for validation. also patients significant coronary artery disease (CAD) invasive angiography. Myocardial time-signal intensity curves images quantified pixel-by-pixel basis using model-constrained deconvolution analysis. Results Qualitatively, color maps comparable microsphere bull's-eye plots all animals. Pixel-wise estimates correlated well against (0.49 ± 0.14 g) measurements (r = 0.87 0.90) showed minor underestimation MBF. To reduce bias due misregistration minimize issues related repeated measures, 1 hyperemic remote sector per animal compared MBF, which improved correlation 0.97 0.98), close zero. Sector-wise pixel-wise 0.97). In patients, stress regional decreases transmural gradients territories served stenotic arteries. endocardial versus epicardial subsectors, ischemic sectors, significantly different (p Conclusions (∼32 μl myocardium) images, results measurements. High-resolution CAD.