Airway Inflammation in Chronic Obstructive Pulmonary Disease

摘要: AM J RESPIR CRIT CARE MED 1999;160:S17−S20.Cigarette smoking causes an inflammatory process in the central airways, peripheral and lung parenchyma, even smokers with normal function. The characteristics of this differ between who develop chronic airflow limitation (COPD) those do not limitation: there is increased infiltration CD8-positive T lymphocytes COPD. We examine whether airway inflammation alters increasing severity disease. When disease becomes severe, a prominent neutrophilia occurs. precise roles CD8+ lymphocyte neutrophil pathogenesis COPD still remain to be determined. Saetta M. Airway obstructive pulmonary