The Antipsychotic Effects of Omega-3 Fatty Acids in Rats.

摘要: Abstract: Background In humans, omega-3 fatty acids are necessary for cell membranes, brain function and nerve transmission continuation. When animals exposed to a new environment—or as result of an apomorphine application that creates agonistic effect on D1 D2 receptors—they display behavioral reactions like rearing stereotypy. This study aims reveal the possible antipsychotic oxidative effects by comparing with chlorpromazine, conventional drug, through evaluating novelty-induced apomorphine-induced stereotypic behaviors, well malondialdehyde glutathione levels in rats. Methods Twenty-eight, adult, male, Wistar rats were used study. Briefly, 4 groups (n = 7) administered docosahexaenoic acid (DHA) + eicosapentaenoic (EPA) (300 mg/kg; DHA: 120 mg/kg EPA: 180 mg/kg intraperitoneally [IP]), DHA EPA (150 mg/kg; 60 mg/kg 90 mg/kg IP), chlorpromazine (1 mg/kg, IP) isotonic saline (1 mL/kg, IP). One hour later, (2 mg/kg, subcutaneously) was each rat. After administration, observed behavior. Results shows acids, “similar antipsychotics,” reversed psychotic effects, increase oxidants decrease antioxidants composed experimentally Conclusions The has causes imbalance. adds evidence current literature regarding acids.