Predictive and prognostic factors for treatment and survival in 305 patients with advanced gastrointestinal poorly differentiated neuroendocrine carcinoma: The NORDIC NEC study.

摘要: 4015 Background: Gastrointestinal poorly differentiated neuroendocrine carcinoma (GI-NEC) are aggressive tumors with Ki-67>20% and usually metastatic at diagnosis. Knowledge about GI-NEC is limited. We retrospectively reviewed clinical data to identify predictive prognostic markers for advanced patients. Methods: Epidemiological, biochemical, histopathological, treatment survival were registered patients diagnosed during 2000-2009 12 Nordic university hospitals. Results: 305 included. Palliative chemotherapy was given 252 patients, median 11 months. Response rate 1st-line 31%, 33% had stable disease. Ki-67<55% by ROC analyses the best cut-off value concerning correlation response rate. platinum-based lower in (14% vs.44%, p<0.001). 84 2nd-line 18%, whereas achieved SD. The most important negative ...