An effective human uracil-DNA glycosylase inhibitor targets the open pre-catalytic active site conformation.
作者： John A. Tainer , John A. Tainer , Davide Moiani , Andrew S. Arvai , John Pink
DOI: 10.1016/J.PBIOMOLBIO.2021.02.004
关键词:
摘要: … , New York, NY, 2019.). We ran a single docking experiment for each ligand to each of the … (PyMOL, The PyMOL Molecular Graphics System, Version 2.0 Schr÷dinger, LLC.) to generate …
sci-hub.st 参考文章(94)
Dynamics in Enzyme Catalysis Springer. ,(2013) , 10.1007/978-3-642-38962-7
B. Kavli, G. Slupphaug, C. D. Mol, A. S. Arvai, S. B. Peterson, J. A. Tainer, H. E. Krokan, Excision of cytosine and thymine from DNA by mutants of human uracil-DNA glycosylase. The EMBO Journal. ,vol. 15, pp. 3442- 3447 ,(1996) , 10.1002/J.1460-2075.1996.TB00710.X
Thomas A. Kunkel, Samuel H. Wilson, Passing the baton in base excision repair Nature Structural & Molecular Biology. ,vol. 7, pp. 176- 178 ,(2000) , 10.1038/73260
Kevin S Wilson, Koichi Ito, Harry F Noller, Yoshikazu Nakamura, None, Functional sites of interaction between release factor RF1 and the ribosome Nature Structural & Molecular Biology. ,vol. 7, pp. 866- 870 ,(2000) , 10.1038/82818
Hans E. KROKAN, Rune STANDAL, Geir SLUPPHAUG, DNA glycosylases in the base excision repair of DNA Biochemical Journal. ,vol. 325, pp. 1- 16 ,(1997) , 10.1042/BJ3250001
D.E. Mcree, S.M. Redford, E.D. Getzoff, J.R. Lepock, R.A. Hallewell, J.A. Tainer, CHANGES IN CRYSTALLOGRAPHIC STRUCTURE AND THERMOSTABILITY OF A CU,ZN SUPEROXIDE DISMUTASE MUTANT RESULTING FROM THE REMOVAL OF BURIED CYSTEINE Journal of Biological Chemistry. ,vol. 265, pp. 14234- 14241 ,(1990) , 10.2210/PDB3SOD/PDB
M. M. Thayer, H. Ahern, D. Xing, R. P. Cunningham, J. A. Tainer, Novel DNA binding motifs in the DNA repair enzyme endonuclease III crystal structure. The EMBO Journal. ,vol. 14, pp. 4108- 4120 ,(1995) , 10.1002/J.1460-2075.1995.TB00083.X
Allison G. Condie, Yan Yan, Stanton L. Gerson, Yanming Wang, A Fluorescent Probe to Measure DNA Damage and Repair. PLOS ONE. ,vol. 10, ,(2015) , 10.1371/JOURNAL.PONE.0131330
Clifford D. Mol, Tadahide Izumi, Sankar Mitra, John A. Tainer, DNA-bound structures and mutants reveal abasic DNA binding by APE1 DNA repair and coordination Nature. ,vol. 403, pp. 451- 456 ,(2000) , 10.1038/35000249
L D Weeks, G E Zentner, P C Scacheri, S L Gerson, Uracil DNA glycosylase (UNG) loss enhances DNA double strand break formation in human cancer cells exposed to pemetrexed Cell Death and Disease. ,vol. 5, ,(2014) , 10.1038/CDDIS.2013.477