Differential methylation of STOX1 in human placenta.

摘要: The 10q22 chromosomal region with genomic linkage to pre-eclampsia in Dutch females shows a parent-of-origin effect maternal transmission of the Y153H susceptibility allele STOX1 gene. Although CpG island within promoter no differential methylation, this study describes identification differentially methylated (DMR) intron 1 Methylation coincides expression, where high methylation leads reduced expression. In SGHPL-5 extravillous trophoblast cell line allele-specific expression was observed subset cells. could be detected early placenta samples, these samples did show an increase when they were homozygous for allele. Allele-specific column being paternal origin. We conclude that is paternally imprinted, maternally expressed, wit...