Combating emerging viral threats

作者: E. Bekerman , S. Einav

DOI: 10.1126/SCIENCE.AAA3778

关键词:

摘要: Although hundreds of viruses are known to cause human disease, antiviral therapies approved for fewer than 10. Most drugs target viral enzymes, most commonly proteases and polymerases. Such direct acting antivirals (DAAs) have shown considerable success in the treatment HIV hepatitis C virus (HCV) infections. However, this approach does not scale easily is limited particularly with respect emerging reemerging against which no vaccines or approved.

参考文章(14)
S. Pollock, N. B. Nichita, A. Bohmer, C. Radulescu, R. A. Dwek, N. Zitzmann, Polyunsaturated liposomes are antiviral against hepatitis B and C viruses and HIV by decreasing cholesterol levels in infected cells Proceedings of the National Academy of Sciences of the United States of America. ,vol. 107, pp. 17176- 17181 ,(2010) , 10.1073/PNAS.1009445107
Jinhong Chang, Timothy M. Block, Ju-Tao Guo, Antiviral therapies targeting host ER alpha-glucosidases: current status and future directions. Antiviral Research. ,vol. 99, pp. 251- 260 ,(2013) , 10.1016/J.ANTIVIRAL.2013.06.011
Aiman A. Haqqani, John C. Tilton, Entry inhibitors and their use in the treatment of HIV-1 infection Antiviral Research. ,vol. 98, pp. 158- 170 ,(2013) , 10.1016/J.ANTIVIRAL.2013.03.017
Yousuke Furuta, Brian B. Gowen, Kazumi Takahashi, Kimiyasu Shiraki, Donald F. Smee, Dale L. Barnard, Favipiravir (T-705), a novel viral RNA polymerase inhibitor. Antiviral Research. ,vol. 100, pp. 446- 454 ,(2013) , 10.1016/J.ANTIVIRAL.2013.09.015
Travis K Warren, Jay Wells, Rekha G Panchal, Kelly S Stuthman, Nicole L Garza, Sean A Van Tongeren, Lian Dong, Cary J Retterer, Brett P Eaton, Gianluca Pegoraro, Shelley Honnold, Shanta Bantia, Pravin Kotian, Xilin Chen, Brian R Taubenheim, Lisa S Welch, Dena M Minning, Yarlagadda S Babu, William P Sheridan, Sina Bavari, None, Protection against filovirus diseases by a novel broad-spectrum nucleoside analogue BCX4430 Nature. ,vol. 508, pp. 402- 405 ,(2014) , 10.1038/NATURE13027
Robert M. Friedman, Clinical uses of interferons British Journal of Clinical Pharmacology. ,vol. 65, pp. 158- 162 ,(2008) , 10.1111/J.1365-2125.2007.03055.X
Gregory Neveu, Rina Barouch-Bentov, Amotz Ziv-Av, Doron Gerber, Yves Jacob, Shirit Einav, Identification and Targeting of an Interaction between a Tyrosine Motif within Hepatitis C Virus Core Protein and AP2M1 Essential for Viral Assembly PLoS Pathogens. ,vol. 8, pp. e1002845- ,(2012) , 10.1371/JOURNAL.PPAT.1002845
Jean-François Rossignol, Nitazoxanide: a first-in-class broad-spectrum antiviral agent. Antiviral Research. ,vol. 110, pp. 94- 103 ,(2014) , 10.1016/J.ANTIVIRAL.2014.07.014