Hemophagocytic Lymphohistiocytosis Syndrome in Dengue Hemorrhagic Fever: Authors’ Reply

摘要: To the Editor: This is in reply to letter by B. Joob and V. Wiwanitkit on our study entitled “Hemophagocytic lymphohistiocytosis syndrome dengue hemorrhagic fever” [1]. HLH a life-threatening complication with variable clinical presentation [2] secondary infections (viral, bacterial, fungal or protozoan) tropical countries. In an Indian report Ramachandran et al., was reported as leading cause for [3]. Veerakul al. also similar experience [4]. Persistence of fever beyond 7–8 d usually due sepsis associated HLH. study, all 23 children presented more than 8 d, malena 86.95 %, organomegaly children, progressive cytopenias abnormal chemistry, namely triglyceride, fibrinogen ferritin. All admitted intensive units had blood urine cultures done routine only those who did not have bacterial growth both were taken study. That excludes sepsis. areas where endemic, awareness dengue-associated fatality, needs be highlighted its course severe induced multi organ dysfunction, but responds well steroids IV immunoglobulin.