Histone chaperones: an escort network regulating histone traffic

摘要: In eukaryotes, DNA is organized into chromatin in a dynamic manner that enables it to be accessed for processes such as transcription and repair. Histones, the chief protein component of chromatin, must assembled, replaced or exchanged preserve change this organization according cellular needs. Histone chaperones are key actors during histone metabolism. Here we classify known discuss how they build network escort proteins. Molecular interactions with histones their potential specificity redundancy also discussed light chaperone structural properties. The multiplicity partners, including modifiers, nucleosome remodelers cell-cycle regulators, relevant coordination processes. Given current interest source epigenetic marks, address contributions memory genome stability.