Hyperecho as the indicator of tissue necrosis during microbubble-assisted high intensity focused ultrasound: sensitivity, specificity and predictive value.
作者： Tinghe Yu , Chuanshan Xu
DOI: 10.1016/J.ULTRASMEDBIO.2008.01.012
关键词:
摘要: The purpose of this study was to determine the sensitivity, specificity and predictive values hyperecho in grayscale ultrasonic images as indicator tissue necrosis microbubble-assisted high-intensity focused ultrasound (HIFU) exposure vivo. Livers kidneys rabbit were exposed HIFU (control group) or (experimental group); a continuous line ablation, viz. linear scan, performed destruct tissues. Tissue responses evaluated macroscopically microscopically 24 h after HIFU. cases positive (hyperecho occurred necrotized), false (tissue unaffected although appeared), negative (echo not changed intact) destructed despite lack hyperecho) counted, then calculated. specificity, value 49.25% vs. 79.63% (p < 0.001), 45.45% 30.00%, 84.62% 86.00% 12.82% 21.43% for liver 76.06% 81.25%, 26.53% 41.67%, 60.00% 82.28% = 0.002) 43.33% 40.00% kidney, control experimental groups, respectively. Rates varied between types group. These findings indicated that use microbubble during improved sensitivity kidney. poor. Hyperecho could only be used some types.
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sci-hub.se 参考文章(20)
D. Razansky, P.D. Einziger, D.R. Adam, Enhanced heat deposition using ultrasound contrast agent - modeling and experimental observations IEEE Transactions on Ultrasonics Ferroelectrics and Frequency Control. ,vol. 53, pp. 137- 147 ,(2006) , 10.1109/TUFFC.2006.1588399
A Keshavarzi, S Vaezy, P J Kaczkowski, G Keilman, R Martin, E Y Chi, R Garcia, V Y Fujimoto, Attenuation coefficient and sound speed in human myometrium and uterine fibroid tumors. Journal of Ultrasound in Medicine. ,vol. 20, pp. 473- 480 ,(2001) , 10.7863/JUM.2001.20.5.473
Tinghe Yu, Xionglin Fan, Shuhua Xiong, Kai Hu, Zhibiao Wang, Microbubbles assist goat liver ablation by high intensity focused ultrasound European Radiology. ,vol. 16, pp. 1557- 1563 ,(2006) , 10.1007/S00330-006-0176-7
Xiao Dong Zhou, Xiao Long Ren, Jun Zhang, Guang Bin He, Min Juan Zheng, Xue Tian, Li Li, Ting Zhu, Min Zhang, Lei Wang, Wen Luo, Therapeutic response assessment of high intensity focused ultrasound therapy for uterine fibroid: Utility of contrast-enhanced ultrasonography European Journal of Radiology. ,vol. 62, pp. 289- 294 ,(2007) , 10.1016/J.EJRAD.2006.11.039
Toni Feder, Science community lobbies for balance in Bush budget Physics Today. ,vol. 54, pp. 29- 30 ,(2001) , 10.1063/1.4761825
J.E. Kennedy, F. Wu, G.R. ter Haar, F.V. Gleeson, R.R. Phillips, M.R. Middleton, D. Cranston, High-intensity focused ultrasound for the treatment of liver tumours. Ultrasonics. ,vol. 42, pp. 931- 935 ,(2004) , 10.1016/J.ULTRAS.2004.01.089
Yukio Kaneko, Toshiyuki Maruyama, Kenji Takegami, Toshiaki Watanabe, Hiroshi Mitsui, Kazuyuki Hanajiri, Hirokazu Nagawa, Yoichiro Matsumoto, Use of a microbubble agent to increase the effects of high intensity focused ultrasound on liver tissue European Radiology. ,vol. 15, pp. 1415- 1420 ,(2005) , 10.1007/S00330-005-2663-7
James E Kennedy, Gail R ter Haar, Feng Wu, Fergus V Gleeson, Ian S.D Roberts, Mark R Middleton, David Cranston, Contrast-enhanced ultrasound assessment of tissue response to high-intensity focused ultrasound. Ultrasound in Medicine and Biology. ,vol. 30, pp. 851- 854 ,(2004) , 10.1016/J.ULTRASMEDBIO.2004.03.011
>C. C. Coussios, C. H. Farny, G. Ter Haar, R. A. Roy, Role of acoustic cavitation in the delivery and monitoring of cancer treatment by high-intensity focused ultrasound (HIFU) International Journal of Hyperthermia. ,vol. 23, pp. 105- 120 ,(2007) , 10.1080/02656730701194131
Lili Chen, Gail ter Haar, Christopher R. Hill, Influence of ablated tissue on the formation of high-intensity focused ultrasound lesions. Ultrasound in Medicine and Biology. ,vol. 23, pp. 921- 931 ,(1997) , 10.1016/S0301-5629(97)00016-1