Candidate Biomarkers for Oral Squamous Cell Carcinoma: Differential Expression of Oxidative Stress-Related Genes

摘要: Background: Alteration in the biotransformation of exogenous compounds can result production reactive oxygen species (ROS), which predispose cells to malignant transformation head and neck. This study aimed evaluate expression genes involved antioxidant metabolism oral squamous cell carcinoma (OSCC). Methods: The eighty-four was evaluated OSCC non-tumor tissues by quantitative real-time polymerase chain reaction using TaqMan Gene Expression Array. biological mechanisms related differentially expressed were investigated – NCBI, KEGG, UNIPROT REACTOME databases. Results: Twenty-one encoding enzymes case. Four (ATOX1, PRDX4, PRNP, SOD2) up-regulated, seventeen (ALOX12, CAT, CSDE1, DHCR24, DUOX1, DUOX2, EPHX2, GLRX2, GPX3, GSR, GSTZ1, MGST3, PRDX1, OXR1, OXSR1, SOD1, SOD3) down-regulated. We identified 14 possible novel biomarkers for OSCC. appeared important processes carcinogenesis, such as inflammation, angiogenesis, apoptosis, genomic instability, invasion, survival, proliferation. Conclusions: Our might warrant further investigation regarding pathogenesis since altered modulate oxidative stress cavity.