摘要: Cholecystokinin (CCK) is a peptide hormone which has long been known to be present in the pancreas and gastro-intestinal tract recently found brain (Morley 1982). High concentrations are animal human cerebral cortex, basal ganglia, hypothalamus limbic lobe (hippocampus, amygdala, olfactory tubercle associated cortices) (Geola et al. 1981). The major CCK entity COOH-terminal octapeptide CCK-8, although lesser amounts of tetrapeptide CCK-4 1981; Rehfeld 1978) found. There good evidence that acts as neu- rotransmitter or neuromodulator CNS; it synthesised neurones concentrated synaptic vesicles, its release calcium-dependent (Emson 1980 b) potent excitatory effect on postsynaptic membranes hip- pocampal cells (Dodd Kelly In addition there have several reports high-affinity binding sites for radiolabelled brains rodents man (Hays
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sci-hub.st 参考文章(54)
J F Rehfeld, Immunochemical studies on cholecystokinin. II. Distribution and molecular heterogeneity in the central nervous system and small intestine of man and hog. Journal of Biological Chemistry. ,vol. 253, pp. 4022- 4030 ,(1978) , 10.1016/S0021-9258(17)34793-2
JACQUELINE N. CRAWLEY, Comparative Distribution of Cholecystokinin and Other Neuropeptides Annals of the New York Academy of Sciences. ,vol. 448, pp. 1- 8 ,(1985) , 10.1111/J.1749-6632.1985.TB29900.X
Robert H. Perry, Graham J. Dockray, Rodney Dimaline, Elaine K. Perry, Garry Blessed, Bernard E. Tomlinson, Neuropeptides in Alzheimer's disease, depression and schizophrenia. A post mortem analysis of vasoactive intestinal peptide and cholecystokinin in cerebral cortex. Journal of the Neurological Sciences. ,vol. 51, pp. 465- 472 ,(1981) , 10.1016/0022-510X(81)90123-4
MA Zarbin, RB Innis, JK Wamsley, SH Snyder, MJ Kuhar, Autoradiographic localization of cholecystokinin receptors in rodent brain The Journal of Neuroscience. ,vol. 3, pp. 877- 906 ,(1983) , 10.1523/JNEUROSCI.03-04-00877.1983
I. N. FERRIER, T. J. CROW, S. M. FARMERY, G. W. ROBERTS, F. OWEN, T. E. ADRIAN, S. R. BLOOM, Reduced Cholecystokinin Levels in the Limbic Lobe in Schizophrenia. Annals of the New York Academy of Sciences. ,vol. 448, pp. 495- 506 ,(1985) , 10.1111/J.1749-6632.1985.TB29943.X
TAKASHI MOROJI, KOICHI ITOH, KOZO ITOH, Antipsychotic Effects of Ceruletide in Chronic Schizophrenia Annals of the New York Academy of Sciences. ,vol. 448, pp. 518- 534 ,(1985) , 10.1111/J.1749-6632.1985.TB29945.X
P. DE WITTE, E. SWANET, M. GEWISS, S. GOLDMAN, B. ROQUES, J-J. VANDERHAEGHEN, Psychopharmacological profile of cholecystokinin using the self-stimulation and the drug discrimination paradigms. Annals of the New York Academy of Sciences. ,vol. 448, pp. 470- 487 ,(1985) , 10.1111/J.1749-6632.1985.TB29941.X
T J Crow, Molecular pathology of schizophrenia: more than one disease process? BMJ. ,vol. 280, pp. 66- 68 ,(1980) , 10.1136/BMJ.280.6207.66
Jane Dodd, J.S. Kelly, The actions of cholecystokinin and related peptides on pyramidal neurones of the mammalian hippocampus. Brain Research. ,vol. 205, pp. 337- 350 ,(1981) , 10.1016/0006-8993(81)90344-9
Margot Albus, Ceruletide: A New Drug for the Treatment of Schizophrenic Patients? Archives of General Psychiatry. ,vol. 41, pp. 528- 528 ,(1984) , 10.1001/ARCHPSYC.1984.01790160114018