Dementia and Pharmacotherapy: Memory Drugs
作者： Jerry J. Buccafusco
DOI: 10.1002/9780470101001.HCN061
关键词:
摘要: Cognition and memory-enhancing agents are in use for the treatment of Alzheimer's disease related disorders. Presently approved drugs belong to pharmacological class acetylcholinesterase inhibitors. However, over past decade numerous potential therapeutic targets have been identified several novel various stages development, including subtype selective muscarinic nicotinic cholinergic receptor agonists, glutamic acid agonists. This review focuses on furthest along drug-development pipeline, but also discussed new compounds their with high disease. Data presented comparing cognition/memory-enhancing from different classes a non-human primate model. The concept that having multiple will be necessary obtain significant improvement efficacy currently available is discussed. Keywords: memory; cognition; drug development; clinical trials; Alzheimer's disease; acetylcholinesterase inhibitors; muscarinic receptors; nicotinic receptors; glutamate receptors; non-human primates; delayed matching-to-sample
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