Regulation of nicotinic acetylcholine receptors by protein phosphorylation

摘要: Neurotransmitter receptors and ion channels play a critical role in the transduction of signals at chemical synapses. The modulation neurotransmitter receptor channel function by protein phosphorylation is one major regulatory mechanisms control synaptic transmission. nicotinic acetylcholine (nAcChR) has provided an excellent model system which to study since structure this have been so extensively characterized. In article, nAcChR from electric organ fish, skeletal muscle, central peripheral nervous will be briefly reviewed. Emphasis placed on regulation second messengers neurotransmitters hormones. addition, recent studies functional