Biologic functions of the OKT1 T cell surface antigen. I. The T1 molecule is involved in helper function.

摘要: The OKT1 (Leu-1) monoclonal antibody reacts with a 69 KD glycoprotein that is present on only fraction of functionally mature thymocytes but maintained most peripheral T cells. In the study presented, we examined role this surface molecule in cell function. We found addition to B cells and autologous T4+ markedly enhances differentiation. This enhancement was apparent when nonirradiated or irradiated not T8+ were used. Moreover, as well F(ab')2 fragment enhanced differentiation dose-dependent fashion. It important note perturbation T1 presence E- causes rapid release molecules trigger proliferate differentiate into Ig-secreting These data considered together suggest membrane determinant complex intimately involved execution helper function OKT4+