Age-related Macular Degeneration Is Associated with Atherosclerosis The Rotterdam Study

摘要: Age-related macular degeneration is the most frequent cause of blindness in elderly. A vascular basis disease has been suggested, but not confirmed. The association between atherosclerosis and this type was investigated 104 subjects with 1,324 without as part population-based Rotterdam Study. study performed March 1990 July 1993 a suburb Rotterdam, Netherlands. Macular assessed on fundus photographs. Carotid ultrasonographically evaluated by measurement common carotid intima-media thickness assessment presence atherosclerotic plaques. Atherosclerosis arteries lower extremities studied determination ankle-arm systolic blood pressure ratio. In younger than age 85 years, plaques bifurcation were associated 4.7 times increased prevalence odds (95% confidence interval (CI) 1.8-12.2); those artery showed an 2.5 CI 1.4-4.5). significantly different. Lower extremity arterial (ankle-arm index less 0.90 at least one side) These findings suggest that may be involved etiology age-related degeneration.